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盐皮质激素和血管紧张素II对动机和中脑边缘活动的不同影响

作者:陈亚云 编译 来源:医学论坛网 日期:2016-05-14
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         Differential effects of mineralocorticoid and angiotensin II on incentive and mesolimbic activity Laura A. Grafea,1,Loretta M. Flanagan-Catoa,b,c,, Abstract The controls of thirst and sodium appetite

Differential effects of mineralocorticoid and angiotensin II on incentive and mesolimbic activity

Laura A. Grafea1Loretta M. Flanagan-Catoabc, , 

Abstract

The controls of thirst and sodium appetite are mediated in part by the hormones aldosteroneand angiotensin II (AngII). The present study examined the behavioral and neural mechanisms of altered effort-value in animals treated with systemic mineralocorticoids, intracerebroventricular AngII, or both. First, rats treated with mineralocorticoid and AngII were tested in the progressive ratio operant task. The willingness to work for sodium versus water depended on hormonal treatment. In particular, rats treated with both mineralocorticoid and AngII preferentially worked for access to sodium versus water compared with rats given only one of these hormones. Second, components of themesolimbic dopamine pathway were examined for modulation by mineralocorticoids and AngII. Based on cFos immunohistochemistry, AngII treatment activated neurons in theventral tegmental area and nucleus accumbens, with no enhancement by mineralocorticoid pretreatment. In contrast, Western blot analysis revealed that combined hormone treatmentincreased levels of phospho-tyrosine hydroxylase in the ventral tegmental area. Thus, mineralocorticoid and AngII treatments differentially engaged the mesolimbic pathwaybased on tyrosine hydroxylase levels versus cFos activation.

Hormones and Behavior

Volume 79, March 2016, Pages 18–27

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